South Texas ISD Virtual Academy is the district's stand-alone virtual school established in the fall of 2021.

Like the six existing STISD schools, South Texas ISD Virtual Academy serves students from Cameron, Hidalgo and Willacy Counties. It will eventually serve students in grades 6-12; however, during the 2023-2024 school year will serve grades 6 through 11 and will phase in additional grades as these cohorts progress through the school years and new ones enroll.

Because it is a public school district, there is no cost for students to attend, and students are accepted for admission on a first-come, first-served basis. Best of all, STISD schools maintain an open enrollment policy, meaning any student with the desire to learn and work hard can attend so long as he or she resides within the tri-county area served. 

In the initial years, the Virtual Academy will offer students the opportunity to take their core courses and several electives, with the opportunity to participate in Dual Credit courses in the future. Instruction and programs will be designed specifically for a virtual setting, with teachers bringing with them to the school expertise in this area. Teachers will teach from a centralized location, while students will participate in their courses 100 percent virtually from home.